TV series

Common Side Effects

Name: Common Side Effects
Released: 2025
Cast: Dave King, Emily Pendergast, Mike Judge, Martha Kelly, Joseph Lee Anderson

2025–· 2 seasons· 23 min episodesTV-MA★ 8.5Returning series

On Adult Swim — From Bandera Entertainment · Green Street Pictures

📺 Season 2 premieres Jan 24, 2027

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Where to watch

Not available to stream in US

Synopsis

Former high school lab partners Marshall and Frances begin to unravel a conspiracy involving big pharma and the federal government to suppress knowledge of a rare mushroom that may hold the key to curing all the world’s diseases.

Themes

mushroom pharmaceutical industry dark comedy conspiracy adult animation government conspiracy miracle cure comedy thriller optimistic

Episodes

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E1 PilotNext upFeb 2, 2025 · 22 min · ★ 7.9
Synopsis
Marshall meets his old high school classmate Frances and lets her in on a world-changing secret.
Guest stars: Shalita Grant (Female DEA Agent (voice)), Ben Feldman (Nick (voice)), Shannon Woodward (Diane (voice))
E2 Lakeshore LimitedFeb 2, 2025 · 23 min · ★ 7.6
Synopsis
Marshall's forced on the run as the DEA pursues him.
Guest stars: Alan Resnick (Zane (voice)), Timothy Simons (DEA Dispatcher (voice)), Bob Stephenson (Connor (voice)), Ben Feldman (Nick (voice)), Sydney Tamiia Poitier (Cecily (voice)), Sue Rose (Hildy (voice)), Shannon Woodward (Amelia (voice)), Danny Huston (Jonas Backstein (voice))
E3 HildyFeb 9, 2025 · 23 min · ★ 7.9
Synopsis
Marshall visits an old mentor as new pressures mount.
Guest stars: Andy Daly (Mysterious Passenger (voice)), Shalita Grant (Susan (voice)), Lin Shaye (Sonia (voice)), Bob Stephenson (Samurai (voice)), Ben Feldman (Nick (voice)), Sydney Tamiia Poitier (Cecily (voice)), Sue Rose (Hildy (voice)), Shannon Woodward (Amelia (voice))
E4 DumpsiteFeb 16, 2025 · 23 min · ★ 7.6
Synopsis
Frances tracks down Marshall in an unlikely location.
Guest stars: Shalita Grant (Susan (voice)), Lin Shaye (Sonia (voice)), Ben Feldman (Nick (voice)), Sue Rose (Hildy (voice)), Steve Hely (Rusty (voice)), Shannon Woodward (Linda Tree (voice))
E5 Star-Tel-LiteFeb 23, 2025 · 22 min · ★ 7.1
Synopsis
Marshall, Frances, and their crazy neighbors deal with the aftermath of a dangerous incident.
Guest stars: Nicolas Cantu (Tommy (voice)), Sydney Tamiia Poitier (Cecily (voice)), Sue Rose (Hildy (voice)), Danny Huston (Jonas Backstein (voice)), Steve Hely (Rusty (voice))
E6 In the SystemMar 2, 2025 · 23 min · ★ 7.5
Synopsis
Stuck in jail, Marshall faces new threats.
Guest stars: Lin Shaye (Sonia (voice)), Jon Foor (Hoang (voice)), Timothy Simons (Lawyer (voice)), Sydney Tamiia Poitier (Cecily (voice)), Sue Rose (Hildy (voice)), Danny Huston (Jonas Backstein (voice)), Steve Hely (Rusty (voice)), Christine Ko (Kiki (voice))
E7 BlowfishMar 9, 2025 · 23 min · ★ 7.4
Synopsis
A chance encounter offers a risky opportunity for escape.
Guest stars: Jon Foor (Hoang (voice)), Andy Daly (Christopher (voice)), Shalita Grant (Kelly (voice)), Sydney Tamiia Poitier (Cecily (voice)), Shannon Woodward (Amelia (voice)), Christine Ko (Kiki (voice)), Ben Feldman (Bud Budrigger (voice))
E8 Amelia & WyattMar 16, 2025 · 22 min · ★ 7.2
Synopsis
Marshall and his new ally make a bold move.
Guest stars: Alan Resnick (Zane (voice)), Jon Foor (Hoang (voice)), Shalita Grant (Kelly (voice)), Ben Feldman (Nick (voice)), Sydney Tamiia Poitier (Cecily (voice)), Sue Rose (Hildy (voice)), Shannon Woodward (Amelia (voice)), Danny Huston (Jonas Backstein (voice))
E9 Cliff's EdgeMar 23, 2025 · 23 min · ★ 7.6
Synopsis
Marshall's mushroom project grows out of hand.
Guest stars: Alan Resnick (Zane (voice)), Shalita Grant (Oncologist (voice)), Timothy Simons (Test Subject 3 (voice)), Sydney Tamiia Poitier (Cecily (voice)), Sue Rose (Hildy (voice)), Shannon Woodward (Amelia (voice)), Danny Huston (Jonas Backstein (voice)), Steve Hely (Rusty (voice))
E10 RaidMar 30, 2025 · 23 min · ★ 7.9
Synopsis
Dangerous forces converge on Marshall's camp.
Guest stars: Bob Stephenson (Line Guy 2 (voice)), Ben Feldman (Nick (voice)), Sue Rose (Hildy (voice)), Shannon Woodward (Amelia (voice)), Danny Huston (Jonas Backstein (voice)), Steve Hely (Rusty (voice)), Christine Ko (Kiki (voice))